BDBM785350 US12466840, Example Ex-7

SMILES CCc1c(F)ccc2cc3[nH]nc(C)c3c(-c3nc4c5c(nc(OC[C@@]67CCCN6C/C(=CF)C7)nc5c3F)N3CCCOC[C@H]3CO4)c12

InChI Key InChIKey=XCUZBLYOKXZENL-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 785350   

TargetGTPase KRas [G12R](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785350BDBM785350(US12466840, Example Ex-7)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [G12S](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785350BDBM785350(US12466840, Example Ex-7)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [G12A](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785350BDBM785350(US12466840, Example Ex-7)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785350BDBM785350(US12466840, Example Ex-7)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785350BDBM785350(US12466840, Example Ex-7)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [G13D](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785350BDBM785350(US12466840, Example Ex-7)
Affinity DataIC50: 2.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785350BDBM785350(US12466840, Example Ex-7)
Affinity DataIC50: 2.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [G12V](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785350BDBM785350(US12466840, Example Ex-7)
Affinity DataIC50: 2.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785350BDBM785350(US12466840, Example Ex-7)
Affinity DataIC50: 11nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase HRas(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785350BDBM785350(US12466840, Example Ex-7)
Affinity DataIC50: 2.18E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase NRas(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785350BDBM785350(US12466840, Example Ex-7)
Affinity DataIC50: 8.98E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent