BDBM786902 2-(7-((2S,5R)-4-(1-(3-chloroimidazo[1,2-b]pyridazin-6-yl)ethyl)-2,5-diethylpiperazin-1-yl)-4-methyl-5-oxo-4,5-dihydro-2H-pyrazolo[4,3-d]pyrimidin-2-yl)acetonitrile::US20250346597, Compound A174b

SMILES CC[C@H]1CN([C@H](C)c2ccc3ncc(Cl)n3n2)[C@H](CC)CN1c1nc(=O)n(C)c2cn(CC#N)nc12

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 786902   

LigandChemical structure of BindingDB Monomer ID 786902BDBM786902(2-(7-((2S,5R)-4-(1-(3-chloroimidazo[1,2-b]pyridazi...)
Affinity DataIC50: 8.90nMAssay Description:Enzymatic reactions of DGKζ, DGKα and DGKδ were performed using ADP-Glo assay with lipid micelle substrate. Full length DGK (in-house protein M1-V929...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 786902BDBM786902(2-(7-((2S,5R)-4-(1-(3-chloroimidazo[1,2-b]pyridazi...)
Affinity DataIC50: 53nMAssay Description:Enzymatic reactions of DGKζ, DGKα and DGKδ were performed using ADP-Glo assay with lipid micelle substrate. Full length DGK (in-house protein M1-V929...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details