BDBM788029 2-chloro-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-3-(1-isopropyl-2-oxo-2',3',5',6'-tetrahydrospiro[dihydroindole-3,4'-pyran]-6-yl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-methylbenzamide::US12473298, Compound 52

SMILES CCN(c1cc(-c2ccc3c(c2)N(C(C)C)C(=O)C32CCOCC2)c(Cl)c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C)C1CCOCC1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 788029   

TargetHistone-lysine N-methyltransferase EZH2 [Y641N](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788029BDBM788029(2-chloro-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-...)
Affinity DataIC50: 0.230nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788029BDBM788029(2-chloro-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-...)
Affinity DataIC50: 0.440nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788029BDBM788029(2-chloro-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-...)
Affinity DataIC50: 0.640nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788029BDBM788029(2-chloro-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-...)
Affinity DataIC50: 0.970nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent