BDBM788041 3-((2,2-dimethyltetrahydro-2H-pyran-4-yl)(ethyl)amino)-5-(1-isopropyl-2-carbonyl-2'',3'',5'',6''-tetrahydrospiro[dihydroindole-3,4''-pyran]-6-yl)-N-((4-methoxy-6-methyl-2-carbonyl-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide::US12473298, Compound 64

SMILES CCN(c5cc(c1ccc2c(c1)N(C(C)C)C(=O)C23CCOCC3)cc(C(=O)NCc4c(OC)cc(C)[nH]c4=O)c5C)C6CCOC(C)(C)C6

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 788041   

TargetHistone-lysine N-methyltransferase EZH2 [Y641N](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788041BDBM788041(3-((2,2-dimethyltetrahydro-2H-pyran-4-yl)(ethyl)am...)
Affinity DataIC50: 0.260nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788041BDBM788041(3-((2,2-dimethyltetrahydro-2H-pyran-4-yl)(ethyl)am...)
Affinity DataIC50: 0.460nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788041BDBM788041(3-((2,2-dimethyltetrahydro-2H-pyran-4-yl)(ethyl)am...)
Affinity DataIC50: 0.530nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788041BDBM788041(3-((2,2-dimethyltetrahydro-2H-pyran-4-yl)(ethyl)am...)
Affinity DataIC50: 0.680nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent