BDBM789986 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 89

SMILES Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2

InChI Key

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 789986   

LigandChemical structure of BindingDB Monomer ID 789986BDBM789986((10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidi...)
Affinity DataIC50: 0.0600nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 789986BDBM789986((10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidi...)
Affinity DataIC50: 0.450nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 789986BDBM789986((10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidi...)
Affinity DataIC50: 4.66nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 789986BDBM789986((10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidi...)
Affinity DataIC50: 6.67nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 789986BDBM789986((10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidi...)
Affinity DataIC50: 19.7nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 789986BDBM789986((10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidi...)
Affinity DataIC50: 64nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 789986BDBM789986((10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidi...)
Affinity DataIC50: 191nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details