BDBM790019 (10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 126

SMILES Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2

InChI Key

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790019   

LigandChemical structure of BindingDB Monomer ID 790019BDBM790019((10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 0.120nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790019BDBM790019((10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 0.320nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790019BDBM790019((10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 0.490nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790019BDBM790019((10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 2.07nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790019BDBM790019((10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 2.80nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790019BDBM790019((10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 16.1nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790019BDBM790019((10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 18.6nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790019BDBM790019((10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 19.8nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790019BDBM790019((10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 133nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790019BDBM790019((10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 164nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790019BDBM790019((10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 188nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details