BDBM790049 (10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 165

SMILES CCN1Cc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1

InChI Key

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790049   

LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 0.0200nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 0.100nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 0.190nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 0.440nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 0.470nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 2.33nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 4.84nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 6.08nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 19nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 28.5nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 72.4nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details