BDBM790066 (10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4'',3''-n][1,4]oxazacyclopentadecine::US20250353864, Example 183

SMILES CCOc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790066   

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790066BDBM790066((10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,1...)
Affinity DataIC50: 0.240nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790066BDBM790066((10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,1...)
Affinity DataIC50: 0.650nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790066BDBM790066((10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,1...)
Affinity DataIC50: 0.820nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790066BDBM790066((10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,1...)
Affinity DataIC50: 1.05nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790066BDBM790066((10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,1...)
Affinity DataIC50: 1.83nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790066BDBM790066((10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,1...)
Affinity DataIC50: 17.7nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790066BDBM790066((10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,1...)
Affinity DataIC50: 53.8nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790066BDBM790066((10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,1...)
Affinity DataIC50: 61.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790066BDBM790066((10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,1...)
Affinity DataIC50: 155nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790066BDBM790066((10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,1...)
Affinity DataIC50: 195nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790066BDBM790066((10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,1...)
Affinity DataIC50: 534nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent