BDBM790068 (10S,17E)-16-{[3- (methanesulfonyl)cyclobutyl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 187
SMILES C[C@H]1CN(C)Cc2c(c(OC3CC(S(C)(=O)=O)C3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1
InChI Key
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 790068
Affinity DataIC50: 0.300nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Affinity DataIC50: 0.470nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Affinity DataIC50: 0.480nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.35nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Affinity DataIC50: 6.88nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
Blossomhill Therapeutics
US Patent
Blossomhill Therapeutics
US Patent
Affinity DataIC50: 7.84nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Affinity DataIC50: 8.88nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Affinity DataIC50: 25.9nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
Blossomhill Therapeutics
US Patent
Blossomhill Therapeutics
US Patent
Affinity DataIC50: 74.7nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Affinity DataIC50: 311nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair