BDBM790091 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,12,13,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-11(10H)- one::US20250353864, Example 220

SMILES CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)C(=O)N(C)C2

InChI Key

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790091   

LigandChemical structure of BindingDB Monomer ID 790091BDBM790091((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-1...)
Affinity DataIC50: 1nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790091BDBM790091((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-1...)
Affinity DataIC50: 2.76nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790091BDBM790091((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-1...)
Affinity DataIC50: 4.31nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790091BDBM790091((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-1...)
Affinity DataIC50: 8.84nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790091BDBM790091((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-1...)
Affinity DataIC50: 23.1nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790091BDBM790091((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-1...)
Affinity DataIC50: 27.5nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790091BDBM790091((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-1...)
Affinity DataIC50: 398nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790091BDBM790091((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-1...)
Affinity DataIC50: 475nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790091BDBM790091((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-1...)
Affinity DataIC50: 515nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790091BDBM790091((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-1...)
Affinity DataIC50: 574nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790091BDBM790091((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-1...)
Affinity DataIC50: 1.44E+3nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details