BDBM790121 (2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3'',4''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 268

SMILES C[C@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790121   

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790121BDBM790121((2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-...)
Affinity DataIC50: 0.180nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790121BDBM790121((2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-...)
Affinity DataIC50: 0.520nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790121BDBM790121((2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-...)
Affinity DataIC50: 0.570nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790121BDBM790121((2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-...)
Affinity DataIC50: 1.04nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790121BDBM790121((2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-...)
Affinity DataIC50: 1.22nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790121BDBM790121((2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-...)
Affinity DataIC50: 1.32nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790121BDBM790121((2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-...)
Affinity DataIC50: 2.01nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790121BDBM790121((2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-...)
Affinity DataIC50: 4.35nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790121BDBM790121((2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-...)
Affinity DataIC50: 7.91nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790121BDBM790121((2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-...)
Affinity DataIC50: 30.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790121BDBM790121((2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-...)
Affinity DataIC50: 45.1nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent