BDBM790134 (17E)-8,14-dimethyl-2,8,10,11,13,14- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole-16- carbonitrile::US20250353864, Example 302

SMILES Cn1nc(C#N)c2c1COCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2

InChI Key

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 790134   

LigandChemical structure of BindingDB Monomer ID 790134BDBM790134((17E)-8,14-dimethyl-2,8,10,11,13,14- hexahydro-3,5...)
Affinity DataIC50: 1.19nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790134BDBM790134((17E)-8,14-dimethyl-2,8,10,11,13,14- hexahydro-3,5...)
Affinity DataIC50: 1.23nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790134BDBM790134((17E)-8,14-dimethyl-2,8,10,11,13,14- hexahydro-3,5...)
Affinity DataIC50: 1.33nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790134BDBM790134((17E)-8,14-dimethyl-2,8,10,11,13,14- hexahydro-3,5...)
Affinity DataIC50: 19.9nMAssay Description:TBAMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790134BDBM790134((17E)-8,14-dimethyl-2,8,10,11,13,14- hexahydro-3,5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details