BDBM790144 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 208

SMILES C[C@H]1CN(C)Cc2c(c(C#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 790144   

LigandChemical structure of BindingDB Monomer ID 790144BDBM790144((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2...)
Affinity DataIC50: 0.130nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790144BDBM790144((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2...)
Affinity DataIC50: 0.590nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790144BDBM790144((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2...)
Affinity DataIC50: 1.53nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790144BDBM790144((10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2...)
Affinity DataIC50: 220nMAssay Description:Table 3: Kinase protein and substrate were pre-diluted in the HEPES assay buffer (100 mM HEPES, pH 7.5, 0.01% Triton X-100, 0.1% BSA, 5 mM MgCl2, 1 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details