BDBM790213 (S) or (R) 1-(4-{6-chloro-2-[(1- cyclopropyl-5-methyl-1H- pyrazol-4-yl)amino]quinazolin- 7-yl}piperidin-1-yl)-4,4,4- trifluorobutan-2-ol::US12540131, Ex-4.191

SMILES Cc1c(Nc2ncc3cc(Cl)c(C4CCN(CC(O)CC(F)(F)F)CC4)cc3n2)cnn1C1CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 790213   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790213BDBM790213((S) or (R) 1-(4-{6-chloro-2-[(1- cyclopropyl-5-met...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent