BDBM790265 (3S,4S)(2S) or (3R,4R)(2S) 4-[4- {2-[(5-chloro-1-cyclopropyl-1H- pyrazol-4-yl)amino]-6- methylquinazolin-7-yl}-2- methylpiperidin-1-yl]oxolan-3-ol::US12540131, Ex-4.243

SMILES Cc1cc2cnc(Nc3cnn(C4CC4)c3Cl)nc2cc1C1CCN([C@@H]2COC[C@@H]2O)[C@@H](C)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 790265   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790265BDBM790265((3S,4S)(2S) or (3R,4R)(2S) 4-[4- {2-[(5-chloro-1-c...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent