BDBM790350 (3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S) or (3R,4R)(3R,4R) 4- [4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)- 5-chloro-1H-pyrazol-4-yl]amino}-6- methylquinazolin-7-yl)-3- fluoropiperidin-1-yl]oxolan-3-ol::US12540131, Ex-8.33

SMILES Cc1cc2cnc(Nc3cnn(C45CC(C4)C5)c3Cl)nc2cc1[C@@H]1CCN([C@@H]2COC[C@@H]2O)C[C@H]1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 790350   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790350BDBM790350((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Cells of Chem3 Cell Line (HTS145C:Millipore) in which mGluR1 was stably expressed were adjusted to a density of 2×106/ml. 50 μl of the cells wer...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent