BDBM790354 (3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S) or (3R,4R)(3R,4R) 4- [4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)- 5-chloro-1H-pyrazol-4-yl]amino}-6- chloroquinazolin-7-yl)-3- fluoropiperidin-1-yl]oxolan-3-ol::US12540131, Ex-8.37

SMILES O[C@H]1COC[C@H]1N1CC[C@H](c2cc3nc(Nc4cnn(C56CC(C5)C6)c4Cl)ncc3cc2Cl)[C@@H](F)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 790354   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790354BDBM790354((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Cells of Chem3 Cell Line (HTS145C:Millipore) in which mGluR1 was stably expressed were adjusted to a density of 2×106/ml. 50 μl of the cells wer...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent