BDBM790355 N-[1-(bicyclo[1.1.1]pentan-1-yl)-5- chloro-1H-pyrazol-4-yl]-6-chloro-7- [1-(3-methyloxetan-3-yl)piperidin-4- yl]quinazolin-2-amine::US12540131, Ex-8.38

SMILES CC1(N2CCC(c3cc4nc(Nc5cnn(C67CC(C6)C7)c5Cl)ncc4cc3Cl)CC2)COC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 790355   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790355BDBM790355(N-[1-(bicyclo[1.1.1]pentan-1-yl)-5- chloro-1H-pyra...)
Affinity DataIC50: 0.631nMAssay Description:Cells of Chem3 Cell Line (HTS145C:Millipore) in which mGluR1 was stably expressed were adjusted to a density of 2×106/ml. 50 μl of the cells wer...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent