BDBM791215 N-{2-[(4-{3-[2-fluoro-5-(trifluoromethyl)phenyl]-1H-pyrrolo[3,2-b]pyridin-2-yl}pyridin-3-yl)oxy]ethyl}-N-methylethenesulfonamide::US20260035365, Example 59

SMILES C=CS(=O)(=O)N(C)CCOc1cnccc1-c1[nH]c2cccnc2c1-c1cc(C(F)(F)F)ccc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 791215   

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
Bayer Aktiengesellschaft; The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 791215BDBM791215(N-{2-[(4-{3-[2-fluoro-5-(trifluoromethyl)phenyl]-1...)
Affinity DataIC50: 0.499nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
Bayer Aktiengesellschaft; The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 791215BDBM791215(N-{2-[(4-{3-[2-fluoro-5-(trifluoromethyl)phenyl]-1...)
Affinity DataIC50: 1.60nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent