BDBM791258 1-{(2S)-2-[({4-[3-(3-ethynylphenyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-3-yl}oxy)methyl]pyrrolidin-1-yl}prop-2-en-1-one::US20260035365, Example 102

SMILES C#Cc1cccc(-c2c(-c3ccncc3OC[C@@H]3CCCN3C(=O)C=C)[nH]c3cccnc23)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 791258   

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
Bayer Aktiengesellschaft; The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 791258BDBM791258(1-{(2S)-2-[({4-[3-(3-ethynylphenyl)-1H-pyrrolo[3,2...)
Affinity DataIC50: 0.417nMAssay Description:Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
Bayer Aktiengesellschaft; The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 791258BDBM791258(1-{(2S)-2-[({4-[3-(3-ethynylphenyl)-1H-pyrrolo[3,2...)
Affinity DataIC50: 1.29nMAssay Description:Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent