BDBM791285 1-{(2S)-2-[({4-[3-(5-chloro-2-fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-5-fluoropyridin-3-yl}oxy)methyl]pyrrolidin-1-yl}prop-2-en-1-one::US20260035365, Example 129

SMILES C=CC(=O)N1CCC[C@H]1COc1cncc(F)c1-c1[nH]c2cccnc2c1-c1cc(Cl)ccc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 791285   

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
Bayer Aktiengesellschaft; The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 791285BDBM791285(1-{(2S)-2-[({4-[3-(5-chloro-2-fluorophenyl)-1H-pyr...)
Affinity DataIC50: 1nMAssay Description:Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
Bayer Aktiengesellschaft; The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 791285BDBM791285(1-{(2S)-2-[({4-[3-(5-chloro-2-fluorophenyl)-1H-pyr...)
Affinity DataIC50: 92.6nMAssay Description:Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent