BDBM795423 US12570659, Example 18

SMILES CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnn2cc(-c3ccc(F)cn3)cc12

InChI Key InChIKey=NQLXVLMKMLAYAP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 795423   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 795423BDBM795423(US12570659, Example 18)
Affinity DataIC50: 12nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/20/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 795423BDBM795423(US12570659, Example 18)
Affinity DataIC50: 5.00E+4nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/20/2026
Entry Details
US Patent