BDBM801877 (R)-N-(3-(5-fluoro-2-((6-(1-hydroxyethyl)pyridin- 3-yl)amino)pyrimidin-4-yl)-1H-indol-7-yl)-3- methoxy-2-(4-methylpiperazin-1-yl)propanamide (isomer 2)::US12606544, Example 9

SMILES COC[C@H](C(=O)Nc1cccc2c(-c3nc(Nc4ccc(C(C)O)nc4)ncc3F)c[nH]c12)N1CCN(C)CC1

InChI Key InChIKey=NZKVNUHIKRXUDJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 801877   

TargetTyrosine-protein kinase JAK1(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801877BDBM801877((R)-N-(3-(5-fluoro-2-((6-(1-hydroxyethyl)pyridin- ...)
Affinity DataIC50: 0.25nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801877BDBM801877((R)-N-(3-(5-fluoro-2-((6-(1-hydroxyethyl)pyridin- ...)
Affinity DataIC50: 20nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801877BDBM801877((R)-N-(3-(5-fluoro-2-((6-(1-hydroxyethyl)pyridin- ...)
Affinity DataIC50: 330nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801877BDBM801877((R)-N-(3-(5-fluoro-2-((6-(1-hydroxyethyl)pyridin- ...)
Affinity DataIC50: 9.95E+3nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent