BDBM801878 US12606544, Example 12::methyl (R)-5-((5-fluoro-4-(7-(3-methoxy-2-(4- methylpiperazin-1-yl)propanamido)-1H-indol-3- yl)pyrimidin-2-yl)amino)picolinate

SMILES COC[C@H](C(=O)Nc1cccc2c(-c3nc(Nc4ccc(C(=O)OC)nc4)ncc3F)c[nH]c12)N1CCN(C)CC1

InChI Key InChIKey=DSTKDFMBYLOUFH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 801878   

TargetTyrosine-protein kinase JAK1(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801878BDBM801878(methyl (R)-5-((5-fluoro-4-(7-(3-methoxy-2-(4- meth...)
Affinity DataIC50: 0.170nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801878BDBM801878(methyl (R)-5-((5-fluoro-4-(7-(3-methoxy-2-(4- meth...)
Affinity DataIC50: 469nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801878BDBM801878(methyl (R)-5-((5-fluoro-4-(7-(3-methoxy-2-(4- meth...)
Affinity DataIC50: 3.77E+3nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801878BDBM801878(methyl (R)-5-((5-fluoro-4-(7-(3-methoxy-2-(4- meth...)
Affinity DataIC50: 1.00E+4nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent