BDBM801895 US12606544, Example 31::ethyl (R)-2-(5-((5-fluoro-4-(7-(3-methoxy-2-(4- methylpiperazin-1-yl)propanamido)-1H-indol-3- yl)pyrimidin-2-yl)amino)pyridin-2-yl)acetate

SMILES CCOC(=O)Cc1ccc(Nc2ncc(F)c(-c3c[nH]c4c(NC(=O)[C@@H](COC)N5CCN(C)CC5)cccc34)n2)cn1

InChI Key InChIKey=GCWIOJQTUYALAF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 801895   

TargetTyrosine-protein kinase JAK1(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801895BDBM801895(ethyl (R)-2-(5-((5-fluoro-4-(7-(3-methoxy-2-(4- me...)
Affinity DataIC50: 0.150nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801895BDBM801895(ethyl (R)-2-(5-((5-fluoro-4-(7-(3-methoxy-2-(4- me...)
Affinity DataIC50: 218nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801895BDBM801895(ethyl (R)-2-(5-((5-fluoro-4-(7-(3-methoxy-2-(4- me...)
Affinity DataIC50: 1.31E+3nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801895BDBM801895(ethyl (R)-2-(5-((5-fluoro-4-(7-(3-methoxy-2-(4- me...)
Affinity DataIC50: 1.00E+4nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent