BDBM801903 (R)-N-(3-(5-fluoro-2-((6-(2-(methylamino)-2-oxoethyl)pyridin-3-yl)amino) pyrimidin-4-yl)-1H-indol-7-yl)-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide::US12606544, Example 39

SMILES CNC(=O)Cc1ccc(Nc2ncc(F)c(-c3c[nH]c4c(NC(=O)[C@@H](COC)N5CCN(C)CC5)cccc34)n2)cn1

InChI Key InChIKey=NFNBFGFJTAQJIK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 801903   

TargetTyrosine-protein kinase JAK1(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801903BDBM801903((R)-N-(3-(5-fluoro-2-((6-(2-(methylamino)-2-oxoeth...)
Affinity DataIC50: 0.230nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801903BDBM801903((R)-N-(3-(5-fluoro-2-((6-(2-(methylamino)-2-oxoeth...)
Affinity DataIC50: 316nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801903BDBM801903((R)-N-(3-(5-fluoro-2-((6-(2-(methylamino)-2-oxoeth...)
Affinity DataIC50: 974nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801903BDBM801903((R)-N-(3-(5-fluoro-2-((6-(2-(methylamino)-2-oxoeth...)
Affinity DataIC50: 1.00E+4nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent