BDBM801929 2-(difluoromethoxy)-4- [6-(1,1-dimethyl-2- morpholino- ethoxy)pyrazolo[1,5- a]pyridin-3-yl]-N- [(1R,2S)-2- fluorocyclopropyl]-6- methoxy-benzamide::US12606554, Compound 3

SMILES COc1cc(-c2cnn3cc(OC(C)(C)CN4CCOCC4)ccc23)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F

InChI Key InChIKey=ULHKXQAOOHVMDP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 801929   

TargetSerine/threonine-protein kinase SIK3(Human)
Onco3R Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 801929BDBM801929(2-(difluoromethoxy)-4- [6-(1,1-dimethyl-2- morphol...)
Affinity DataIC50: 55nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Onco3R Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 801929BDBM801929(2-(difluoromethoxy)-4- [6-(1,1-dimethyl-2- morphol...)
Affinity DataIC50: 300nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Onco3R Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 801929BDBM801929(2-(difluoromethoxy)-4- [6-(1,1-dimethyl-2- morphol...)
Affinity DataIC50: 500nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent