BDBM802076 US20260108613, Compound A23::methyl (S)-3-((2S,4R)-4- hydroxy-1-((R)-3,7,7-trimeth- yl-5,6,7,8-tetrahydro-4H- cyclohepta[d]isoxazole-8- carbonyl)pyrrolidine-2-carbox- amido)-3-(4-(4-methylthiazol- 5-yl)phenyl)propanoate

SMILES Cc1ncsc1-c1ccc([C@H](CC(=O)O)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]2c3onc(C)c3CCCC2(C)C)cc1

InChI Key InChIKey=JQRUJLKNCOGNKU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 802076   

Targetvon Hippel-Lindau disease tumor suppressor(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 802076BDBM802076(methyl (S)-3-((2S,4R)-4- hydroxy-1-((R)-3,7,7-trim...)
Affinity DataIC50: 15.5nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent