BDBM803667 2-((2-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-6-methoxy-2H-indazol-5-yl)carbamoyl)-6-methylpyridine 1-oxide::US12617770, Compound 001

SMILES COc1cc2nn([C@H]3CC[C@](C)(O)CC3)cc2cc1NC(=O)c1cccc(C)[n+]1[O-]

InChI Key InChIKey=XYPANWHZPSKPMX-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 803667   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Wuhan Createrna Science and Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803667BDBM803667(2-((2-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-6-met...)
Affinity DataIC50: 6nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Wuhan Createrna Science and Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803667BDBM803667(2-((2-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-6-met...)
Affinity DataIC50: 30nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetCytochrome P450 1A2(Human)
Wuhan Createrna Science and Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803667BDBM803667(2-((2-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-6-met...)
Affinity DataIC50: 30nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Wuhan Createrna Science and Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803667BDBM803667(2-((2-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-6-met...)
Affinity DataIC50: 30nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetCytochrome P450 2C19(Human)
Wuhan Createrna Science and Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803667BDBM803667(2-((2-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-6-met...)
Affinity DataIC50: 30nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Wuhan Createrna Science and Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803667BDBM803667(2-((2-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-6-met...)
Affinity DataIC50: 30nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Wuhan Createrna Science and Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803667BDBM803667(2-((2-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-6-met...)
Affinity DataIC50: 4.04E+3nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent