BDBM803701 2-((2-(3-hydroxy-3-methylbutyl)-6-methoxy-2H-indazol-5-yl)carbamoyl)-6-methylpyridine 1-oxide::US12617770, Compound 163

SMILES COc1cc2nn(CCC(C)(C)O)cc2cc1NC(=O)c1cccc(C)[n+]1[O-]

InChI Key InChIKey=GWGIFLUFRLQAKE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 803701   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Wuhan Createrna Science and Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803701BDBM803701(2-((2-(3-hydroxy-3-methylbutyl)-6-methoxy-2H-indaz...)
Affinity DataIC50: 23nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetCytochrome P450 1A2(Human)
Wuhan Createrna Science and Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803701BDBM803701(2-((2-(3-hydroxy-3-methylbutyl)-6-methoxy-2H-indaz...)
Affinity DataIC50: 30nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetCytochrome P450 2C19(Human)
Wuhan Createrna Science and Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803701BDBM803701(2-((2-(3-hydroxy-3-methylbutyl)-6-methoxy-2H-indaz...)
Affinity DataIC50: 30nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Wuhan Createrna Science and Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803701BDBM803701(2-((2-(3-hydroxy-3-methylbutyl)-6-methoxy-2H-indaz...)
Affinity DataIC50: 30nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Wuhan Createrna Science and Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803701BDBM803701(2-((2-(3-hydroxy-3-methylbutyl)-6-methoxy-2H-indaz...)
Affinity DataIC50: 30nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Wuhan Createrna Science and Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803701BDBM803701(2-((2-(3-hydroxy-3-methylbutyl)-6-methoxy-2H-indaz...)
Affinity DataIC50: 30nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Wuhan Createrna Science and Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803701BDBM803701(2-((2-(3-hydroxy-3-methylbutyl)-6-methoxy-2H-indaz...)
Affinity DataIC50: 2.99E+3nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent