BDBM803776 US12617784, Example 38

SMILES C[C@@H]1CC(=O)Nc2ncnc(N3CC4CCC(C3)N4C(=O)[C@H](CNC3CC3)c3ccc(Cl)cc3)c21

InChI Key InChIKey=LODHZRAIBZILBA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 803776   

TargetRAC-gamma serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803776BDBM803776(US12617784, Example 38)
Affinity DataIC50: 0.280nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803776BDBM803776(US12617784, Example 38)
Affinity DataIC50: 2.40nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetRAC-beta serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803776BDBM803776(US12617784, Example 38)
Affinity DataIC50: 23nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent