BDBM806491 2-[2-[[5-(4-fluorophenyl)-6-isopropyl-1H-pyrazolo[4,3-g]isoquinolin-8-yl]oxy]-5-oxo-6-azaspiro[3.4]octan-6-yl]propanoic acid (104)::US12624028, Compound 104

SMILES CC(C)c5nc(O[C@@H]2C[C@]1(CCN(C(C)C(=O)O)C1=O)C2)c4cc3[nH]ncc3cc4c5c6ccc(F)cc6

InChI Key InChIKey=RCELQUUENTYTNP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 806491   

TargetAlpha-1-antitrypsin/Neutrophil elastase(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 806491BDBM806491(2-[2-[[5-(4-fluorophenyl)-6-isopropyl-1H-pyrazolo[...)
Affinity DataIC50: 1.16E+3nMAssay Description:Biochemical JAK and Off-Target Kinase Assays. A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kin...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2026
Entry Details
US Patent