BDBM806513 2-[[3-[[5-(4-fluorophenyl)-6-isopropyl-1H-pyrazolo[4,3-g]isoquinolin-8-yl]oxy]cyclobutanecarbonyl]amino]propanoic acid (132)::US12624028, Compound 132

SMILES CC(C)c4nc(O[C@@H]1C[C@@H](C(=O)NC(C)C(=O)O)C1)c3cc2[nH]ncc2cc3c4c5ccc(F)cc5

InChI Key InChIKey=OMQMPZPMSFYXSP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 806513   

TargetAlpha-1-antitrypsin/Neutrophil elastase(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 806513BDBM806513(2-[[3-[[5-(4-fluorophenyl)-6-isopropyl-1H-pyrazolo...)
Affinity DataIC50: 1.16E+3nMAssay Description:Biochemical JAK and Off-Target Kinase Assays. A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kin...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2026
Entry Details
US Patent