BDBM807698 2-((2-Fluoro-4-(trifluoromethyl)benzyl)thio)-3-(5-hydroxypyrazin-2-yl)pyrazolo[5,1-f][1,2,4]triazin-4(3H)-one::US20260132136, Example 28
SMILES O=c1c2ccnn2nc(SCc2ccc(C(F)(F)F)cc2F)n1-c1cnc(O)cn1
InChI Key InChIKey=HUUKLNWRADBRKQ-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 807698
Affinity DataIC50: 42nMAssay Description:NOX4 inhibition is assessed utilizing HEK293 cells stably overexpressing human NOX4 (hNOX4), generating constitutively high levels of hydrogen peroxi...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+4nMAssay Description:Evaluation of the NOX4 inhibitors on NOX3 activity is assessed in HEK293 cells stably overexpressing human NOX3 (hNOX3).Cells are cultured in the DME...More data for this Ligand-Target Pair
Affinity DataIC50: 6.80E+4nMAssay Description:Evaluation of the NOX4 inhibitors on NOX1 activity is assessed in HEK293 cells stably overexpressing human NOX1 (hNOX1).Cells are cultured in the DME...More data for this Ligand-Target Pair
Affinity DataIC50: 8.90E+4nMAssay Description:Evaluation of the NOX4 inhibitors on NOX5 activity is assessed in HEK293 cells stably overexpressing human NOX5 (hNOX5).Cells are cultured in the DME...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Evaluation of the NOX4 inhibitors on NOX2 activity is assessed in human blood-derived granulocytes.Different concentrations of the test compounds (30...More data for this Ligand-Target Pair