BDBM807760 US20260132136, Example 90

SMILES C#Cc1ccc(CSc2nn3ncc(F)c3c(=O)n2-c2cnc(O)cn2)cc1

InChI Key InChIKey=YSOHGOGFHPQIRH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 807760   

TargetNADPH oxidase 4(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 807760BDBM807760(US20260132136, Example 90)
Affinity DataIC50: 36nMAssay Description:NOX4 inhibition is assessed utilizing HEK293 cells stably overexpressing human NOX4 (hNOX4), generating constitutively high levels of hydrogen peroxi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetNADPH oxidase 1(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 807760BDBM807760(US20260132136, Example 90)
Affinity DataIC50: 8.00E+4nMAssay Description:Evaluation of the NOX4 inhibitors on NOX1 activity is assessed in HEK293 cells stably overexpressing human NOX1 (hNOX1).Cells are cultured in the DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent