BDBM807775 US20260132136, Example 105

SMILES Cc1cnn2nc(SCc3ccc(Cl)cc3)n(-c3cnc(O)cn3)c(=O)c12

InChI Key InChIKey=LNQYGSGRUVWUEE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 807775   

TargetNADPH oxidase 4(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 807775BDBM807775(US20260132136, Example 105)
Affinity DataIC50: 15nMAssay Description:NOX4 inhibition is assessed utilizing HEK293 cells stably overexpressing human NOX4 (hNOX4), generating constitutively high levels of hydrogen peroxi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetNADPH oxidase 1(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 807775BDBM807775(US20260132136, Example 105)
Affinity DataIC50: 1.00E+5nMAssay Description:Evaluation of the NOX4 inhibitors on NOX1 activity is assessed in HEK293 cells stably overexpressing human NOX1 (hNOX1).Cells are cultured in the DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetCytochrome b-245 heavy chain(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 807775BDBM807775(US20260132136, Example 105)
Affinity DataIC50: 1.00E+5nMAssay Description:Evaluation of the NOX4 inhibitors on NOX2 activity is assessed in human blood-derived granulocytes.Different concentrations of the test compounds (30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetNADPH oxidase 3(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 807775BDBM807775(US20260132136, Example 105)
Affinity DataIC50: 1.00E+5nMAssay Description:Evaluation of the NOX4 inhibitors on NOX3 activity is assessed in HEK293 cells stably overexpressing human NOX3 (hNOX3).Cells are cultured in the DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetNADPH oxidase 5(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 807775BDBM807775(US20260132136, Example 105)
Affinity DataIC50: 1.00E+5nMAssay Description:Evaluation of the NOX4 inhibitors on NOX5 activity is assessed in HEK293 cells stably overexpressing human NOX5 (hNOX5).Cells are cultured in the DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent