BDBM807871 5-((1-(3-(5-Methyl-2,5- diazaspiro[3.4]octan-2- yl)phenyl)-1H-imidazol- 4-yl)amino)pyrazine-2- carbonitrile::US20260132140, Example 34

SMILES CN1CCCC12CN(c1cccc(-n3cnc(Nc4cnc(C#N)cn4)c3)c1)C2

InChI Key InChIKey=XMDMLCWOUZDWMY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 807871   

TargetSerine/threonine-protein kinase Chk1(Human)
Benevolentai Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 807871BDBM807871(5-((1-(3-(5-Methyl-2,5- diazaspiro[3.4]octan-2- yl...)
Affinity DataIC50: 18nMAssay Description:Table 20: 2 μL enzyme/substrate solution (1 nM Chk-1 (Carna Bioscience #02-177), in solution with 30 μM ATP, 4 μM STK1 S1 (Cisbio #62ST1PEB) in assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk2(Human)
Benevolentai Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 807871BDBM807871(5-((1-(3-(5-Methyl-2,5- diazaspiro[3.4]octan-2- yl...)
Affinity DataIC50: 5.50E+4nMAssay Description:Table 23: 2 μL enzyme/substrate solution (2 nM Chk-1 (Carna Bioscience #02-162), in solution with 200 μM ATP, 4 μM STK1 S1 (Cisbio #62ST1PEB) in assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent