BDBM808000 5-((1-(4-((3R,4S)-3- Methoxy-4- (methylamino)pyrrolid in-1-yl)phenyl)-1H- imidazol-4- yl)amino)pyrazine-2- carbonitrile::US20260132140, Example 163

SMILES CN[C@H]1CN(c2ccc(-n3cnc(Nc4cnc(C#N)cn4)c3)cc2)C[C@H]1OC

InChI Key InChIKey=CEZSTKISSYFZAT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 808000   

TargetSerine/threonine-protein kinase Chk1(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 808000BDBM808000(5-((1-(4-((3R,4S)-3- Methoxy-4- (methylamino)pyrro...)
Affinity DataIC50: 18nMAssay Description:Table 20: 2 μL enzyme/substrate solution (1 nM Chk-1 (Carna Bioscience #02-177), in solution with 30 μM ATP, 4 μM STK1 S1 (Cisbio #62ST1PEB) in assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent