BDBM808002 5-((1-(4-((2R,4R)-4- Amino-2- methylpyrrolidin-1- yl)phenyl)-1H- imidazol-4- yl)amino)pyrazine-2- carbonitrile::US20260132140, Example 165

SMILES C[C@@H]1C[C@@H](N)CN1c1ccc(-n2cnc(Nc3cnc(C#N)cn3)c2)cc1

InChI Key InChIKey=NDNMZHNFGXFFPA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 808002   

TargetSerine/threonine-protein kinase Chk1(Human)
Benevolentai Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 808002BDBM808002(5-((1-(4-((2R,4R)-4- Amino-2- methylpyrrolidin-1- ...)
Affinity DataIC50: 10nMAssay Description:Table 20: 2 μL enzyme/substrate solution (1 nM Chk-1 (Carna Bioscience #02-177), in solution with 30 μM ATP, 4 μM STK1 S1 (Cisbio #62ST1PEB) in assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk2(Human)
Benevolentai Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 808002BDBM808002(5-((1-(4-((2R,4R)-4- Amino-2- methylpyrrolidin-1- ...)
Affinity DataIC50: 5.50E+3nMAssay Description:Table 23: 2 μL enzyme/substrate solution (2 nM Chk-1 (Carna Bioscience #02-162), in solution with 200 μM ATP, 4 μM STK1 S1 (Cisbio #62ST1PEB) in assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent