BDBM808262 (S)-2-((2-(5,5-difluoro-2-oxo-1,3-oxazinan-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide::US12630561, Example 66

SMILES C[C@H](Nc1ccc2c(c1)OCCn1cc(N3CC(F)(F)COC3=O)nc1-2)C(N)=O

InChI Key InChIKey=IJOXXXDRUNJQRO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 808262   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Jiangsu Hansoh Pharmaceutical Group Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808262BDBM808262((S)-2-((2-(5,5-difluoro-2-oxo-1,3-oxazinan-3-yl)-5...)
Affinity DataIC50: 9.30nMAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Jiangsu Hansoh Pharmaceutical Group Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808262BDBM808262((S)-2-((2-(5,5-difluoro-2-oxo-1,3-oxazinan-3-yl)-5...)
Affinity DataIC50: 653nMAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Jiangsu Hansoh Pharmaceutical Group Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808262BDBM808262((S)-2-((2-(5,5-difluoro-2-oxo-1,3-oxazinan-3-yl)-5...)
Affinity DataIC50: 2.08E+3nMAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Jiangsu Hansoh Pharmaceutical Group Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808262BDBM808262((S)-2-((2-(5,5-difluoro-2-oxo-1,3-oxazinan-3-yl)-5...)
Affinity DataIC50: 4.57E+3nMAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent