BDBM808264 (S)-2-((2-((S)-2-(difluoromethyl)-4-methyl-6-oxopiperazin-1-yl)-5,6-dihydrobenzo[f]im idazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide::US12630561, Example 69

SMILES C[C@H](Nc1ccc2c(c1)OCCn1cc(N3C(=O)CN(C)C[C@H]3C(F)F)nc1-2)C(N)=O

InChI Key InChIKey=DYGDOIJQVXWUAS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 808264   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Jiangsu Hansoh Pharmaceutical Group Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808264BDBM808264((S)-2-((2-((S)-2-(difluoromethyl)-4-methyl-6-oxopi...)
Affinity DataIC50: 2.10nMAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Jiangsu Hansoh Pharmaceutical Group Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808264BDBM808264((S)-2-((2-((S)-2-(difluoromethyl)-4-methyl-6-oxopi...)
Affinity DataIC50: 142nMAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Jiangsu Hansoh Pharmaceutical Group Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808264BDBM808264((S)-2-((2-((S)-2-(difluoromethyl)-4-methyl-6-oxopi...)
Affinity DataIC50: 332nMAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Jiangsu Hansoh Pharmaceutical Group Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808264BDBM808264((S)-2-((2-((S)-2-(difluoromethyl)-4-methyl-6-oxopi...)
Affinity DataIC50: 3.18E+3nMAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent