BDBM808463 4-(10-((R)-1-(2-aminopyridin-3- yl)ethyl)-4-fluoro-2-(((2R,7aS)-2- fluorotetrahydro-1H-pyrrolizin-7a(5H)- yl)methoxy)-9,10-dihydro-8H-7-oxa- 1,3,6,10- tetraazacyclohepta[de]naphthalen-5- yl)naphthalen-2-ol::US20260137699, Example 26

SMILES C[C@H](c1cccnc1N)N1CCOc2nc(-c3cc(O)cc4ccccc34)c(F)c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc1c23

InChI Key InChIKey=JFNWRKHEOIHFAB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 808463   

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 808463BDBM808463(4-(10-((R)-1-(2-aminopyridin-3- yl)ethyl)-4-fluoro...)
Affinity DataIC50: 0.110nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 808463BDBM808463(4-(10-((R)-1-(2-aminopyridin-3- yl)ethyl)-4-fluoro...)
Affinity DataIC50: 0.260nMAssay Description:Cryopreserved human PBMCs were obtained from AllCells (cat# PB003F). After thawing/dilution protocols using RPMI medium supplemented with 5% FBS (hea...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent