BDBM808619 5-(azetidin-3-yloxy)-7-(2-fluoro-6- methyl-phenyl)isoquinolin-3-amine::US12637428, Example E47

SMILES Cc1cccc(F)c1-c1cc(OC2CNC2)c2cc(N)ncc2c1

InChI Key InChIKey=RQTJAYFTIVUCCC-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 808619   

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808619BDBM808619(5-(azetidin-3-yloxy)-7-(2-fluoro-6- methyl-phenyl)...)
Affinity DataKi:  0.168nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808619BDBM808619(5-(azetidin-3-yloxy)-7-(2-fluoro-6- methyl-phenyl)...)
Affinity DataKi:  1.01nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808619BDBM808619(5-(azetidin-3-yloxy)-7-(2-fluoro-6- methyl-phenyl)...)
Affinity DataKi:  2.07nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808619BDBM808619(5-(azetidin-3-yloxy)-7-(2-fluoro-6- methyl-phenyl)...)
Affinity DataKi:  13.5nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808619BDBM808619(5-(azetidin-3-yloxy)-7-(2-fluoro-6- methyl-phenyl)...)
Affinity DataKi:  732nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEphrin type-A receptor 2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808619BDBM808619(5-(azetidin-3-yloxy)-7-(2-fluoro-6- methyl-phenyl)...)
Affinity DataKi:  1.08E+3nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent