BDBM808706 6-fluoro-7-(2-fluoro-6-methyl- phenyl)-N5-(4-piperidyl)isoquinoline- 3,5-diamine::US12637428, Example E134

SMILES Cc1cccc(F)c1-c1cc2cnc(N)cc2c(NC2CCNCC2)c1F

InChI Key InChIKey=JYWVZOQKKXZZII-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 808706   

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808706BDBM808706(6-fluoro-7-(2-fluoro-6-methyl- phenyl)-N5-(4-piper...)
Affinity DataKi:  0.132nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808706BDBM808706(6-fluoro-7-(2-fluoro-6-methyl- phenyl)-N5-(4-piper...)
Affinity DataKi:  0.452nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808706BDBM808706(6-fluoro-7-(2-fluoro-6-methyl- phenyl)-N5-(4-piper...)
Affinity DataKi:  0.558nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808706BDBM808706(6-fluoro-7-(2-fluoro-6-methyl- phenyl)-N5-(4-piper...)
Affinity DataKi:  1.94nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808706BDBM808706(6-fluoro-7-(2-fluoro-6-methyl- phenyl)-N5-(4-piper...)
Affinity DataKi:  12.3nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEphrin type-A receptor 2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808706BDBM808706(6-fluoro-7-(2-fluoro-6-methyl- phenyl)-N5-(4-piper...)
Affinity DataKi:  25.1nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent