BDBM809255 (4Z)-4-[(1,3-benzothiazol-6-yl)methylidene]-1-methyl-2-[(propan-2-yl)amino]-4,5-dihydro-1H-imidazol-5-one::(Z)-5-(benzo[d]thiazol-6-ylmethylene)-2-(isopropylamino)-3-methyl-3,5-dihydro-4H-imidazol-4-one::US12643887, Example 45

SMILES CC(C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1C

InChI Key InChIKey=NQULLFCPGFOYFA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 809255   

TargetDual specificity protein kinase CLK1 [129-484](Human)
Tongji University

US Patent
LigandChemical structure of BindingDB Monomer ID 809255BDBM809255((Z)-5-(benzo[d]thiazol-6-ylmethylene)-2-(isopropyl...)
Affinity DataIC50: 100nMAssay Description:Briefly, CLK1 (16 nM) in the enzymatic buffer solutions (40 mM Tris, pH 7.5, 20 mM MgCl2, 0.1 mg/ml BSA, 50 μM DTT) were mixed with various concentra...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/19/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 809255BDBM809255((Z)-5-(benzo[d]thiazol-6-ylmethylene)-2-(isopropyl...)
Affinity DataIC50: 550nMAssay Description:Briefly, DYRK1A (3 nM) in the enzymatic buffer solutions (40 mM Tris, pH 7.5, 20 mM MgCl2, 0.1 mg/ml BSA, 50 μM DTT) were mixed with various concentr...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/19/2026
Entry Details
US Patent

TargetCitron Rho-interacting kinase [1-499](Human)
Tongji University

US Patent
LigandChemical structure of BindingDB Monomer ID 809255BDBM809255((Z)-5-(benzo[d]thiazol-6-ylmethylene)-2-(isopropyl...)
Affinity DataIC50: 550nMAssay Description:Briefly, CIT (20 nM) in the enzymatic buffer solutions (40 mM Tris, pH 7.5, 20 mM MgCl2, 0.1 mg/ml BSA, 50 μM DTT) were mixed with various concentrat...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/19/2026
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Tongji University

US Patent
LigandChemical structure of BindingDB Monomer ID 809255BDBM809255((Z)-5-(benzo[d]thiazol-6-ylmethylene)-2-(isopropyl...)
Affinity DataIC50: 5.50E+3nMAssay Description:Briefly, GSK3 beta (4 nM) in the enzymatic buffer solutions (40 mM Tris, pH 7.5, 20 mM MgCl2, 0.1 mg/ml BSA, 50 μM DTT) were mixed with various conce...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/19/2026
Entry Details
US Patent

TargetHomeodomain-interacting protein kinase 1 [156-555](Human)
Tongji University

US Patent
LigandChemical structure of BindingDB Monomer ID 809255BDBM809255((Z)-5-(benzo[d]thiazol-6-ylmethylene)-2-(isopropyl...)
Affinity DataIC50: 5.50E+3nMAssay Description:Briefly, HIPK1 (4 nM) in the enzymatic buffer solutions (40 mM Tris, pH 7.5, 20 mM MgCl2, 0.1 mg/ml BSA, 50 μM DTT) were mixed with various concentra...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/19/2026
Entry Details
US Patent

TargetHomeodomain-interacting protein kinase 2 [1-640](Human)
Tongji University

US Patent
LigandChemical structure of BindingDB Monomer ID 809255BDBM809255((Z)-5-(benzo[d]thiazol-6-ylmethylene)-2-(isopropyl...)
Affinity DataIC50: 5.50E+3nMAssay Description:Briefly, HIPK2 (1 nM) in the enzymatic buffer solutions (40 mM Tris, pH 7.5, 20 mM MgCl2, 0.1 mg/ml BSA, 50 μM DTT) were mixed with various concentra...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/19/2026
Entry Details
US Patent

TargetCasein kinase II subunit alpha'(Human)
Tongji University

US Patent
LigandChemical structure of BindingDB Monomer ID 809255BDBM809255((Z)-5-(benzo[d]thiazol-6-ylmethylene)-2-(isopropyl...)
Affinity DataIC50: 5.50E+3nMAssay Description:Briefly, CK2a2 (CSNK2a2) (7 nM) in the enzymatic buffer solutions (40 mM Tris, pH 7.5, 20 mM MgCl2, 0.1 mg/ml BSA, 50 μM DTT) were mixed with various...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/19/2026
Entry Details
US Patent