BDBM8134 N-(3,4-dimethoxyphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine::pyrazolo[1,5-b]pyridazine deriv. 25

SMILES COc1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1OC

InChI Key InChIKey=AGAYQQLAAVQQLA-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8134   

TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

LigandPNGBDBM8134(N-(3,4-dimethoxyphenyl)-4-{pyrazolo[1,5-a]pyridazi...)
Affinity DataIC50: 12nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

LigandPNGBDBM8134(N-(3,4-dimethoxyphenyl)-4-{pyrazolo[1,5-a]pyridazi...)
Affinity DataKi:  12nMAssay Description:Inhibition of GSK3beta (unknown origin) expressed in Sf9 cells using GS1 as substrate and [gamma32]ATP after 30 min by scinitllation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM8134(N-(3,4-dimethoxyphenyl)-4-{pyrazolo[1,5-a]pyridazi...)
Affinity DataIC50: 50nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
LigandPNGBDBM8134(N-(3,4-dimethoxyphenyl)-4-{pyrazolo[1,5-a]pyridazi...)
Affinity DataIC50: 199nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed