BDBM81442 CP-690,550

SMILES C[C@@H]1CCC(CC1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N

InChI Key InChIKey=DPFSOTYRUFYURL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 81442   

TargetTyrosine-protein kinase JAK1(Human)
University of Luxembourg

LigandPNGBDBM81442(CP-690,550)
Affinity DataIC50: 6.10nMpH: 7.5 T: 2°CAssay Description:Enzyme assay affinity-purified GST fusions of the active kinase domains (GST-Jak1(866-1154), GST-Jak2(808-1132), GST-Jak3(811-1124) and GST-Tyk2(888-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
University of Luxembourg

LigandPNGBDBM81442(CP-690,550)
Affinity DataIC50: 8nMpH: 7.5 T: 2°CAssay Description:Enzyme assay affinity-purified GST fusions of the active kinase domains (GST-Jak1(866-1154), GST-Jak2(808-1132), GST-Jak3(811-1124) and GST-Tyk2(888-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Luxembourg

LigandPNGBDBM81442(CP-690,550)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:Enzyme assay affinity-purified GST fusions of the active kinase domains (GST-Jak1(866-1154), GST-Jak2(808-1132), GST-Jak3(811-1124) and GST-Tyk2(888-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2011
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
University of Luxembourg

LigandPNGBDBM81442(CP-690,550)
Affinity DataIC50: 176nMpH: 7.5 T: 2°CAssay Description:Enzyme assay affinity-purified GST fusions of the active kinase domains (GST-Jak1(866-1154), GST-Jak2(808-1132), GST-Jak3(811-1124) and GST-Tyk2(888-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2011
Entry Details Article
PubMed