BDBM8156 N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-methoxypyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine::pyrazolo[1,5-b]pyridazine deriv. 47

SMILES COc1cc(Nc2nccc(n2)-c2cnn3nc(OC)ccc23)cc(c1)C(F)(F)F

InChI Key InChIKey=GJYVLTPTDBQQCY-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 8156   

TargetDual specificity protein kinase CLK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM8156(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-metho...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM8156(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-metho...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human CLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM8156(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-metho...)
Affinity DataIC50: 46nMAssay Description:Inhibition of human CLK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

LigandPNGBDBM8156(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-metho...)
Affinity DataIC50: 199nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM8156(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-metho...)
Affinity DataIC50: 363nMAssay Description:Inhibition of human CLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM8156(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-metho...)
Affinity DataIC50: 794nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
LigandPNGBDBM8156(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-metho...)
Affinity DataIC50: 2.00E+4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed