BDBM8160 4-(6-Methylpyrazolo[1,5-b]pyridazin-3-yl)-N-[3-(trifluoromethyl)phenyl]-2-pyrimidinamine::4-{6-methylpyrazolo[1,5-a]pyridazin-3-yl}-N-[3-(trifluoromethyl)phenyl]pyrimidin-2-amine::pyrazolo[1,5-b]pyridazine deriv. 51

SMILES Cc1ccc2c(cnn2n1)-c1ccnc(Nc2cccc(c2)C(F)(F)F)n1

InChI Key InChIKey=YPDVNNOPAKMWBO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8160   

TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

LigandPNGBDBM8160(4-{6-methylpyrazolo[1,5-a]pyridazin-3-yl}-N-[3-(tr...)
Affinity DataIC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
LigandPNGBDBM8160(4-{6-methylpyrazolo[1,5-a]pyridazin-3-yl}-N-[3-(tr...)
Affinity DataIC50: 31nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM8160(4-{6-methylpyrazolo[1,5-a]pyridazin-3-yl}-N-[3-(tr...)
Affinity DataIC50: 50nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed