BDBM8162 N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-methylpyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine::pyrazolo[1,5-b]pyridazine deriv. 53

SMILES COc1cc(Nc2nccc(n2)-c2cnn3nc(C)ccc23)cc(c1)C(F)(F)F

InChI Key InChIKey=ZANNOGKZSUYAAD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8162   

TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

LigandPNGBDBM8162(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-methy...)
Affinity DataIC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM8162(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-methy...)
Affinity DataIC50: 20nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
LigandPNGBDBM8162(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-methy...)
Affinity DataIC50: 398nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed